Isuzu Motor Co., Ltd. yashinzwe mu 1937. Icyicaro cyayo giherereye i Tokiyo, mu Buyapani.Inganda ziherereye mu mujyi wa Fujisawa, intara ya tokumu na Hokkaido.Azwiho gukora ibinyabiziga byubucuruzi na moteri yimbere ya mazutu.Nimwe mubakora ibinyabiziga binini kandi bishaje byubucuruzi ku isi.Mu 1934, ukurikije uburyo busanzwe bwa Minisiteri y’Ubucuruzi n’inganda (ubu ni Minisiteri y’Ubucuruzi, Inganda n’Ubucuruzi), hatangijwe umusaruro mwinshi w’imodoka, maze ikirango “Isuzu” cyitirirwa uruzi rwa Isuzu hafi y’urusengero rwa Yishi .Kuva aho ikirangantego n'izina ryisosiyete bihurijwe hamwe mu 1949, izina ryisosiyete ya Isuzu Automatic Car Co., Ltd. ryakoreshejwe kuva icyo gihe.Nka kimenyetso cyiterambere mpuzamahanga muminsi iri imbere, ikirango cyikipe ubu nikimenyetso cyibishushanyo bigezweho hamwe ninyuguti yikiromani “Isuzu”.Kuva yashingwa, Isosiyete ikora moteri ya Isuzu imaze imyaka irenga 70 ikora ubushakashatsi no guteza imbere no gukora moteri ya mazutu.Nka rimwe mu mashami atatu y’ubucuruzi y’inkingi ya Isuzu Motor Company (andi abiri ni ishami ry’ubucuruzi CV n’ishami ry’ubucuruzi rya LCV), ashingiye ku mbaraga za tekinike zikomeye z’icyicaro gikuru, ishami ry’ubucuruzi rya mazutu ryiyemeje gushimangira ubufatanye bw’ubucuruzi ku isi; no kubaka uruganda rwa mbere rwa moteri ya mazutu.Kugeza ubu, umusaruro w’ibinyabiziga by’ubucuruzi bya Isuzu na moteri ya mazutu biza ku mwanya wa mbere ku isi.